Czerniak, zwany też czerniakiem złośliwym (łac. melanoma malignum) – nowotwór złośliwy skóry, błon śluzowych lub błony naczyniowej oka wywodzący się z melanocytów. ... Read Article
BRAF V600E-mutated Lung Adenocarcinoma With metastases To The ...
V600E-mutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib Sara D. Robinson a, Joyce A. O’Shaughnessy,b, Brain patient metastasis Vemurafenib Non-small cell lung cancer Targeted therapy a b s t r a c t ... Read Document
Embryonal Fyn-associated Substrate - Wikipedia, The Free ...
Embryonal fyn-associated substrate is a protein that in humans is encoded by the EFS gene. (UM) and only UM with EFS methylation gave rise to metastases. [22] kidney and brain. ... Read Article
Dabrafenib And Trametinib, Alone And In Combination For BRAF ...
Dabrafenib and Trametinib, alone and in combination for BRAF-mutant brain metastases (≥3mm size). Of 156 melanoma patients enrolled in the study, Vemurafenib was co-developed with the Cobas® 4800 V600 mutation test, ... View Full Source
Anti-CTLA-4 And BRAF Inhibition In Patients With Metastatic ...
Patients with brain metastases treated with vemurafenib have also been reported [51]. †† Largest trial in patients with metastatic melanoma and brain metastases using ipilimumab, revealing similar results as for patients without brain metastases. ... Fetch Full Source
Vemurafenib Criteria For Use - United States Department Of ...
Exclusion Criteria If the answer to ANY item below is met, then the patient should NOT receive vemurafenib. Untreated brain metastases Prior stereotactic therapy or surgery for brain metastases allowed if no progression of brain metastases for at least 2 months ... Read Document
S302 International Journal Of Radiation Oncology Biology Physics
Title: Safety and Efficacy of Vemurafenib Combined With Stereotactic Radiosurgery for Brain Metastases in BRAF+ Melanoma Author: B. Kavanagh Subject ... View Full Source
Dr. Chapman On Vemurafenib Combination Therapies - YouTube
Paul Chapman, MD, from Memorial Sloan-Kettering Cancer Center on Future Vemurafenib Combination Therapies ... View Video
In Vitro Treatment Of Melanoma Brain Metastasis By ...
Interestingly, there is a few reports in the literature on the treatment of brain metastases using vemurafenib [24–28] and also indicating increased not been studied clinically on patients with brain metastases from melanoma. The two specific protein kinase inhibitors ... Document Retrieval
Vemurafenib In <italic>BRAF</italic>V600 Mutated Metastatic ...
Censored: no brain metastases at baseline A B Vemurafenib in BRAFV600 mutated metastatic melanoma RESEARCh ARTiClE future science group www.futuremedicine.com study and the Italian cohort remain undefined, and will become likely clearer at the final analy - ... View Doc
Vemurafenib In BRAFV600 Mutated Metastatic Melanoma (MM): A ...
Patients with brain metastases at baseline 83 (21.6) Patients with ECOG 0-1 at baseline 356 (92.5) • Vemurafenib – an inhibitor of the BRAF kinase - has been shown in clinical trials to prolong survival in patients with MM (1,2). ... Read Here
MO25743: An Open-label, Single-arm, Phase II, Multicenter ...
Evaluate the Efficacy of Vemurafenib in Metastatic Melanoma Patients With Brain Metastases Purpose: This open-label, single-arm, multicenter study will evaluate the efficacy and safety in patients with metastatic melanoma who developed brain metastases. ... Read More
Roche Announces vemurafenib Improved Survival In People With ...
F. Hoffmann-La Roche Ltd 4070 Basel Switzerland Group Communications Roche Group Media Relations Tel. +41 61 688 88 88 Fax +41 61 688 27 75 www.roche.com 1/5 Basel, 5 June 2011 Roche announces vemurafenib improved survival in people with metastatic ... Fetch Content
Local Control After Stereotactic Radiosurgery For brain ...
Mainstay of treatment for brain metastases. In a study of vemurafenib, patients were eligible only if their disease had progressed despite local therapy. In the study, 25% of the 24 subjects underwent SRS.9 Because of the favorable ... Read More
Vemurafenib For The Treatment Of BRAF Mutant Metastatic Melanoma
Vemurafenib for the treatment of BRAF mutant metastatic melanoma The appearance of brain metastases is a fre-quent and challenging issue in patients with mel - Vemurafenib is able to inhibit the kinase activity of BRAF with V600 mutation. ... Retrieve Full Source
The Use Of Systemic Therapies For The Treatment Of brain ...
The use of systemic therapies for the treatment of brain metastases in metastatic melanoma: Opportunities and unanswered questions Jack Murrella,1, Ruth Boardb, Brain metastases Vemurafenib Dabrafenib BRAF Ipilimumab Blood brain barrier abstract ... Read Content
Efficacy And Safety Of Ipilimumab In Patients With Advanced ...
Efficacy and safety of ipilimumab in patients with advanced melanoma and brain metastases Open-label pilot study of vemurafenib in previously treated metastatic melanoma patients with symptomatic brain metastases. Ann Oncol 23(9 Suppl):1125P ... Visit Document
LINAC-based Stereotactic Radiosurgery To The brain With ...
CLINICAL STUDY LINAC-based stereotactic radiosurgery to the brain with concurrent vemurafenib for melanoma metastases Kamran A. Ahmed • Jessica M. Freilich • Sarah Sloot• ... Doc Retrieval
Vemurafenib In Patients With BRAFV600 Mutation-positive ...
Vemurafenib in patients with BRAFV600 mutation-positive melanoma with symptomatic brain metastases: Final results of an open-label pilot study Reinhard Dummera,*,1, Simone M. Goldingera,1, Christian P. Turtschia, ... Access Document
C-Raf - Wikipedia, The Free Encyclopedia
C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases. Several other molecules followed up, such as Vemurafenib, Regorafenib, Dabrafenib, etc. ... Read Article
Successful Treatment Of A Progressive V600E–Mutated ...
Successful Treatment of a Progressive BRAF V600E–Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy Introduction Pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor ... Read Full Source
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